Description
SENP2 was discovered both through its homology to other SUMO proteases. When overexpressed in tissue culture cells or underin vitro conditions, the murine SENP2 homologue (Smt3IP2) cleaves conjugates of SUMO-1, SUMO-2, and SUMO-3. full length human SENP2 associates with nuclear pores in a manner similar to Ulp1 in yeast. This association occurs exclusively with the nuclear face of the pore and requires sequences near the N-terminus of SENP2